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Potentially Ototoxic Drugs

   Antibiotics
         Aminoglycosides - may produce  
                      cochleotoxicity
         Gentamicin
         Tobramycin
         Macrolides - produces reversible     
              effects in patients with kidney or
              liver damage
         Erythromycin

  Loop Diuretics - high doses can be ototoxic
         Furosemide
         Etharcrynic
         Bumetanide

  Chemotherapeutic agents - can cause high
              frequency hearing loss
  Platinum containing agents
        Cisplatin
        Carboplatin
        Oxaliplatin

 Heavy Metals
         Mercury
         Lead

 High Doses of Aspirin - can cause high
        pitched hearing loss



References
1. Dobie RA, Black FO, Pezsnecker SC, Stallings VL (March 2006). "Hearing loss
in patients with vestibulotoxic reactions to gentamicin therapy". Archives of
Otolaryngology--Head & Neck Surgery 132 (3): 253–7. doi:10.1001/archotol.
132.3.253. PMID 16549744. http://archotol.ama-assn.org/cgi/pmidlookup?
view=long&pmid=16549744.
2. Basile AS, Huang JM, Xie C, Webster D, Berlin C, Skolnick P (December 1996).
"N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced
hearing loss". Nature Medicine 2 (12): 1338–43. PMID 8946832.
3. Wu WJ, Sha SH, Schacht J (2002). "Recent advances in understanding
aminoglycoside ototoxicity and its prevention". Audiology & Neuro-otology 7 (3):
171–4. PMID 12053140. http://content.karger.com/produktedb/produkte.asp?
typ=fulltext&file=aud07171.
4. Munckhof WJ, Grayson ML, Turnidge JD (April 1996). "A meta-analysis of
studies on the safety and efficacy of aminoglycosides given either once daily or
as divided doses". The Journal of Antimicrobial Chemotherapy 37 (4): 645–63.
PMID 8722531. http://jac.oxfordjournals.org/cgi/pmidlookup?
view=long&pmid=8722531.
5. Tepel M (August 2007). "N-Acetylcysteine in the prevention of ototoxicity".
Kidney International 72 (3): 231–2. doi:10.1038/sj.ki.5002299. PMID 17653228.
6. Perez N, Martín E, García-Tapia R (March 2003). "Intratympanic gentamicin for
intractable Ménière's disease". The Laryngoscope 113 (3): 456–64. doi:10.1097
/00005537-200303000-00013. PMID 12616197.
7. a b c d e f g h i j Roland, Peter S. (2004). Ototoxicity. Hamilton, Ont: B.C.
Decker. ISBN 1-55009-263-4.
8. Voelker JR, Cartwright-Brown D, Anderson S, et al. (October 1987).
"Comparison of loop diuretics in patients with chronic renal insufficiency".
Kidney International 32 (4): 572–8. PMID 3430953.
9. a b Rademaker-Lakhai JM, Crul M, Zuur L, et al. (February 2006). "Relationship
between cisplatin administration and the development of ototoxicity". Journal of
Clinical Oncology : Official Journal of the American Society of Clinical Oncology
24 (6): 918–24. doi:10.1200/JCO.2006.10.077. PMID 16484702. http://www.jco.
org/cgi/pmidlookup?view=long&pmid=16484702.
10. a b Hellberg V, Wallin I, Eriksson S, et al. (January 2009). "Cisplatin and
oxaliplatin toxicity: importance of cochlear kinetics as a determinant for
ototoxicity". Journal of the National Cancer Institute 101 (1): 37–47. doi:10.1093
/jnci/djn418. PMID 19116379. PMC 2639295. http://jnci.oxfordjournals.
org/cgi/pmidlookup?view=long&pmid=19116379.
11. Rybak LP, Whitworth CA, Mukherjea D, Ramkumar V (April 2007).
"Mechanisms of cisplatin-induced ototoxicity and prevention". Hearing Research
226 (1-2): 157–67. doi:10.1016/j.heares.2006.09.015. PMID 17113254. http:
//linkinghub.elsevier.com/retrieve/pii/S0378-5955(06)00272-3.
12. Hensley ML, Hagerty KL, Kewalramani T, et al. (January 2009). "American
Society of Clinical Oncology 2008 clinical practice guideline update: use of
chemotherapy and radiation therapy protectants". Journal of Clinical Oncology 27
(1): 127–45. doi:10.1200/JCO.2008.17.2627. PMID 19018081. http://www.jco.
org/cgi/pmidlookup?view=long&pmid=19018081.
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