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Potentially Ototoxic Drugs

         Aminoglycosides - may produce  
         Macrolides - produces reversible     
              effects in patients with kidney or
              liver damage

  Loop Diuretics - high doses can be ototoxic

  Chemotherapeutic agents - can cause high
              frequency hearing loss
  Platinum containing agents

 Heavy Metals

 High Doses of Aspirin - can cause high
        pitched hearing loss

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in patients with vestibulotoxic reactions to gentamicin therapy". Archives of
Otolaryngology--Head & Neck Surgery 132 (3): 253–7. doi:10.1001/archotol.
132.3.253. PMID 16549744.
2. Basile AS, Huang JM, Xie C, Webster D, Berlin C, Skolnick P (December 1996).
"N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced
hearing loss". Nature Medicine 2 (12): 1338–43. PMID 8946832.
3. Wu WJ, Sha SH, Schacht J (2002). "Recent advances in understanding
aminoglycoside ototoxicity and its prevention". Audiology & Neuro-otology 7 (3):
171–4. PMID 12053140.
4. Munckhof WJ, Grayson ML, Turnidge JD (April 1996). "A meta-analysis of
studies on the safety and efficacy of aminoglycosides given either once daily or
as divided doses". The Journal of Antimicrobial Chemotherapy 37 (4): 645–63.
PMID 8722531.
5. Tepel M (August 2007). "N-Acetylcysteine in the prevention of ototoxicity".
Kidney International 72 (3): 231–2. doi:10.1038/ PMID 17653228.
6. Perez N, Martín E, García-Tapia R (March 2003). "Intratympanic gentamicin for
intractable Ménière's disease". The Laryngoscope 113 (3): 456–64. doi:10.1097
/00005537-200303000-00013. PMID 12616197.
7. a b c d e f g h i j Roland, Peter S. (2004). Ototoxicity. Hamilton, Ont: B.C.
Decker. ISBN 1-55009-263-4.
8. Voelker JR, Cartwright-Brown D, Anderson S, et al. (October 1987).
"Comparison of loop diuretics in patients with chronic renal insufficiency".
Kidney International 32 (4): 572–8. PMID 3430953.
9. a b Rademaker-Lakhai JM, Crul M, Zuur L, et al. (February 2006). "Relationship
between cisplatin administration and the development of ototoxicity". Journal of
Clinical Oncology : Official Journal of the American Society of Clinical Oncology
24 (6): 918–24. doi:10.1200/JCO.2006.10.077. PMID 16484702. http://www.jco.
10. a b Hellberg V, Wallin I, Eriksson S, et al. (January 2009). "Cisplatin and
oxaliplatin toxicity: importance of cochlear kinetics as a determinant for
ototoxicity". Journal of the National Cancer Institute 101 (1): 37–47. doi:10.1093
/jnci/djn418. PMID 19116379. PMC 2639295. http://jnci.oxfordjournals.
11. Rybak LP, Whitworth CA, Mukherjea D, Ramkumar V (April 2007).
"Mechanisms of cisplatin-induced ototoxicity and prevention". Hearing Research
226 (1-2): 157–67. doi:10.1016/j.heares.2006.09.015. PMID 17113254. http:
12. Hensley ML, Hagerty KL, Kewalramani T, et al. (January 2009). "American
Society of Clinical Oncology 2008 clinical practice guideline update: use of
chemotherapy and radiation therapy protectants". Journal of Clinical Oncology 27
(1): 127–45. doi:10.1200/JCO.2008.17.2627. PMID 19018081. http://www.jco.
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